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Comparison of blood–nerve barrier disruption and matrix metalloprotease-9 expression in injured central and peripheral nerves in mice
- Source :
-
Neuroscience Letters . Mar2008, Vol. 434 Issue 2, p155-159. 5p. - Publication Year :
- 2008
-
Abstract
- Abstract: To investigate the involvement of blood-born factors and extracellular proteases in axonal degeneration and regeneration in both PNS and CNS, we directly compared the differences of blood–nerve barrier (BNB) disruption and matrix metalloprotease-9 (MMP-9) induction between the sciatic nerve and optic nerve after crush injury in the same animal. In sciatic nerve, BNB disruption, fibrin(ogen) deposition and MMP-9 expression were observed only in the first week following injury. Neurofilament (NF) immunoreactivity dramatically decreased in the first 2 days, gradually recovered to the normal levels by day 28. In contrast, the immunoglobulin G deposits spanned from 4h to 28 days in crushed optic nerves. Fibrin(ogen) deposition was only observed in the first 2 days, while MMP-9 induction did not occur until a week after injury but lasted for 3 weeks in the crushed optic nerves. The NF immunoreactivity did not change much until day 7 and almost completely disappeared on day 28. The decrease of NF immunoreactivity coincided with the induction of MMP-9 after optic nerve crush. These results show that BNB disruption and MMP-9 induction are differentially regulated in the PNS and CNS after injuries, and they may contribute to the different regeneration capacities of the two systems. [Copyright &y& Elsevier]
- Subjects :
- *PERIPHERAL nervous system
*CENTRAL nervous system
*METALLOPROTEINASES
*MICE
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 434
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 31409862
- Full Text :
- https://doi.org/10.1016/j.neulet.2007.12.052