New 8-hydroxybriarane diterpenoids from the gorgonians Junceella juncea and Junceella fragilis (Ellisellidae)

Abstract: Four new 8-hydroxybriarane diterpenoids, including junceols A–C (1–3) and fragilide D (4), have been isolated from the gorgonian corals Junceella juncea and Junceella fragilis, respectively. The structures of briaranes 1–4 were elucidated by the interpretations of spectral data analysis. Briaranes 1–3 have displayed inhibitory effects on superoxide anion generation by human neutrophils. [Copyright &y& Elsevier]