Novel Synthetic Approach to Multibenzoylated Nucleosides.

An improved and highly efficient synthetic approach to multibenzoylated nucleosides bearing free 5'-hydroxyl groups is described here. By employing t-butyldimethylsilyl (TBDMS) rather than the more commonly used dimethoxytrityl (DMTr) as a temporary 5'-OH protecting group of the starting nucleoside, this methodology provides the expected products in nearly quantitative yields, thereby substantially reducing the cost and effort of synthesis. [ABSTRACT FROM AUTHOR]