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Evolution, expression and effectiveness in a cluster of novel bovine β-defensins.
- Source :
-
Immunogenetics . Mar2008, Vol. 60 Issue 3/4, p147-156. 10p. 1 Black and White Photograph, 2 Diagrams, 2 Charts, 1 Graph. - Publication Year :
- 2008
-
Abstract
- The anti-microbial peptides β-defensins constitute a large family of innate immune effector molecules, conserved across a wide species range. In this paper, we describe a systematic search of the sequenced bovine genome to characterise this extensive gene family in Bos taurus, providing an insight into the pattern of conservation of β-defensin genes between species. We have sequenced a sub-set of these newly discovered bovine β-defensin genes and also report expression data for these genes across a range of tissues. We have synthesised the peptide product of one of these genes, bovine β-defensin 123, and found it to be a potent inhibitor of several pathogenic microbes, particularly Escherichia coli and Listeria monocytogenes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00937711
- Volume :
- 60
- Issue :
- 3/4
- Database :
- Academic Search Index
- Journal :
- Immunogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 31722190
- Full Text :
- https://doi.org/10.1007/s00251-007-0269-8