Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations.

Features a study which reported that missense mutations and/or deletions involving several regions of hypoxia-inducible factor 1 (HIF-1) results in constitutive expression and transcriptional activity in nonhypoxic cells. Role of oxygen-regulated ubiquitination on HIF-1alpha protein expression; Methodology of the study; Results and discussion; Conclusion.