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Local therapy of cancer with free IL-2.
- Source :
-
Cancer Immunology, Immunotherapy . Jul2008, Vol. 57 Issue 7, p931-950. 20p. 1 Diagram, 6 Charts, 1 Graph. - Publication Year :
- 2008
-
Abstract
- This is a position paper about the therapeutic effects of locally applied free IL-2 in the treatment of cancer. Local therapy: IL-2 therapy of cancer was originally introduced as a systemic therapy. This therapy led to about 20% objective responses. Systemic therapy however was very toxic due to the vascular leakage syndrome. Nevertheless, this treatment was a break-through in cancer immunotherapy and stimulated some interesting questions: Supposing that the mechanism of IL-2 treatment is both proliferation and tumoricidal activity of the tumor infiltrating cells, then locally applied IL-2 should result in a much higher local IL-2 concentration than systemic IL-2 application... [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANCER treatment
*INTERLEUKIN-2
*CANCER cells
*IMMUNOTHERAPY
*THERAPEUTICS
*TUMORS
Subjects
Details
- Language :
- English
- ISSN :
- 03407004
- Volume :
- 57
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Cancer Immunology, Immunotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 31771732
- Full Text :
- https://doi.org/10.1007/s00262-008-0455-z