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Identification of noninvasive imaging surrogates for brain tumor gene-expression modules.

Authors :
Diehn, Maximilian
Nardini, Christine
Wang, David S.
McGovern, Susan
Jayaraman, Mahesh
Yu Liang
Aldape, Kenneth
Soonmee Cha
Kuo, Michael D.
Source :
Proceedings of the National Academy of Sciences of the United States of America. 4/1/2008, Vol. 105 Issue 13, p5213-5218. 6p. 1 Chart, 1 Graph.
Publication Year :
2008

Abstract

Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor in adults. We combined neuroimaging and DNA microarray analysis to create a multidimensional map of gene-expression patterns in GBM that provided clinically relevant insights into tumor biology. Tumor contrast enhancement and mass effect predicted activation of specific hypoxia and proliferation gene-expression programs, respectively. Overexpression of EGFR, a receptor tyrosine kinase and potential therapeutic target, was also directly inferred by neuroimaging and was validated in an independent set of tumors by immunohistochemistry. Furthermore, imaging provided insights into the intratumoral distribution of gene-expression patterns within GBM. Most notably, an "infiltrative" imaging phenotype was identified that predicted patient outcome. Patients with this imaging phenotype had a greater tendency toward having multiple tumor foci and demonstrated significantly shorter survival than their counterparts. Our findings provide an in vivo portrait of genome-wide gene expression in GBM and offer a potential strategy for noninvasively selecting patients who may be candidates for individualized therapies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00278424
Volume :
105
Issue :
13
Database :
Academic Search Index
Journal :
Proceedings of the National Academy of Sciences of the United States of America
Publication Type :
Academic Journal
Accession number :
31778902
Full Text :
https://doi.org/10.1073/pnas.0801279105