Tandem Michael Addition/Ylide Epoxidation for the Synthesis of Highly Functionalized Cyclohexadiene Epoxide Derivatives.

The article discusses a study which develops a tandem Michael addition/ylide epoxidation for the rapid creation of highly functionalized cyclohexadiene epoxide skeletons with three sterocenters. The study investigated the intramolecular version of the tandem reaction. It is showed that the tandem reaction could access to highly functionalized cyclohexadiene epoxide derivatives with excellent diastereoselectivity and chemoselectivity.