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IFP35 Is Involved in the Antiviral Function of Interferon by Association with the Viral Tas Transactivator of Bovine Foamy Virus.
- Source :
-
Journal of Virology . May2008, Vol. 82 Issue 9, p40-40. 1p. - Publication Year :
- 2008
-
Abstract
- Interferon-induced proteins (IFPs) exert multiple functions corresponding to diverse interferon signals. However, the intracellular functions of many IFPs are not fully characterized. Here, we report that IFP35, a member of the IFP family with a molecular mass of 35 kDa, can interact with the bovine Tas (BTas) regulatory protein of bovine foamy virus (BFV). The interaction involves NID2 (IFP35/Nmi homology domain) of IFP35 and the central domain of BTas. The overexpression of IFP35 disturbs the ability of BTas to activate viral-gene transcription and inhibits viral replication. The depletion of endogenous IFP35 by interfering RNA can promote the activation of BFV, suggesting an inhibitory function of IFP35 in viral-gene expression. In addition, IFP35 can interact with the homologous regulatory protein of prototype FV and arrest viral replication and repress viral transcription. Our study suggests that IFP35 may represent a novel pathway of interferon-mediated antiviral activity in host organisms that plays a role in the maintenance of FV latency. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTERFERONS
*PROTEINS
*FOAMY viruses
*VIRAL replication
*GENE expression
Subjects
Details
- Language :
- English
- ISSN :
- 0022538X
- Volume :
- 82
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 31882459
- Full Text :
- https://doi.org/10.1128/JVI.02249-07