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Prolymphocytic leukaemia of B- and T-cell subtype: a state-of-the-art paper.
- Source :
-
European Journal of Haematology . Jun2008, Vol. 80 Issue 6, p469-476. 8p. 3 Color Photographs, 2 Charts. - Publication Year :
- 2008
-
Abstract
- Prolymphocytic leukaemias of B and T cell subtype are rare diseases. Despite recent advances in immunophenotyping and molecular cytogenetics, leading to a better understanding of the underlying cell biology of the prolymphocytic leukaemias, prognosis for these patients remains poor. Purine analogues and monoclonal antibodies have shown efficacy in B-cell prolymphocytic leukaemia although further studies are warranted. Monoclonal antibody therapy with alemtuzumab has significantly improved outcome in T-cell prolymphocytic leukaemia (T-PLL) but responses are still transient and further disease progression is inevitable. While allogeneic stem cell transplant is an attractive option, due to the older age group of T-PLL patients the morbidity and mortality associated with the procedure is significant. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09024441
- Volume :
- 80
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- European Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 31939459
- Full Text :
- https://doi.org/10.1111/j.1600-0609.2008.01069.x