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Chemical and biological investigation of N-hydroxy-valdecoxib: An active metabolite of valdecoxib
- Source :
-
Bioorganic & Medicinal Chemistry . May2008, Vol. 16 Issue 9, p5322-5330. 9p. - Publication Year :
- 2008
-
Abstract
- Abstract: The inhibition of cyclooxygenase enzymes plays an important role in the treatment of inflammatory diseases. N-Hydroxy-4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide (3)—a primary metabolite of the highly selective COX-2 inhibitor valdecoxib—was synthesized and stabilized as its monohydrate (3a·H2O). The anti-inflammatory properties of 3a·H2O were investigated in carrageenan-induced edema and in acute and chronic pain models. Based on our biological investigation, we conclude that N-hydroxy-valdecoxib 3a is an active metabolite of valdecoxib. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 16
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32050421
- Full Text :
- https://doi.org/10.1016/j.bmc.2008.02.088