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Tandem Nucleophilic Addition/Cyclization Reaction in the Synthesis of Ketimine-Type Iminosugars.
- Source :
-
Journal of Organic Chemistry . 5/2/2008, Vol. 73 Issue 9, p3612-3615. 4p. 1 Chart, 1 Graph. - Publication Year :
- 2008
-
Abstract
- The biological activity of unsaturated iminosugars has not yet been extensively studied because of a lack of general synthetic methods. A practical synthesis of these cyclic ketimine sugars was developed, which was based on a tandem addition-cyclization reaction of a Grignard reagent to a ω-methanesulfonylglycononitrile. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 73
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32137850
- Full Text :
- https://doi.org/10.1021/jo702616x