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Solvent-controlled regioselective protection of 5′-O-protected thymidine
- Source :
-
Carbohydrate Research . Jul2008, Vol. 343 Issue 9, p1490-1495. 6p. - Publication Year :
- 2008
-
Abstract
- Abstract: This paper describes an efficient procedure for selective 3′-O- or 3-N-protection of 5′-O-tert-butyldimethylsilylthymidine, depending on the use of aprotic polar solvents with low or high dielectric constant, respectively. These syntheses were activated by either ultrasound or microwaves. Several alkyl bromides offer a convenient route to prepare 3′-O- or 3-N-protected and functionalized thymidine derivatives. [Copyright &y& Elsevier]
- Subjects :
- *THYMIDINE
*SOLVENTS
*MICROWAVES
*BROMIDES
Subjects
Details
- Language :
- English
- ISSN :
- 00086215
- Volume :
- 343
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Carbohydrate Research
- Publication Type :
- Academic Journal
- Accession number :
- 32495909
- Full Text :
- https://doi.org/10.1016/j.carres.2008.04.026