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Metabolic and signaling properties of an Itpk gene family in Glycine max
- Source :
-
FEBS Letters . Jun2008, Vol. 582 Issue 13, p1853-1858. 6p. - Publication Year :
- 2008
-
Abstract
- Abstract: We have cloned and characterized four Itpk genes from soybean. All four recombinant Itpk proteins showed canonical Ins(1,3,4)P3 5/6-kinase activity, but a kinetic analysis raised questions about its biological significance. Instead, we provide evidence that one alternative biological role for soybean Itpks is to interconvert the Cl− channel inhibitor, Ins(3,4,5,6)P4, and its metabolic precursor, Ins(1,3,4,5,6)P5, within a substrate cycle. The soybean Itpks also phosphorylated Ins(3,4,6)P3 to Ins(1,3,4,6)P4 which was further phosphorylated to Ins(1,3,4,5,6)P5 by soybean Ipk2. Thus, soybean Itpks may participate in an inositol lipid-independent pathway of InsP6 synthesis. [Copyright &y& Elsevier]
- Subjects :
- *METABOLISM
*SOYBEAN
*VITAMIN B complex
*BIOMOLECULES
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 582
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 32496280
- Full Text :
- https://doi.org/10.1016/j.febslet.2008.04.054