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A virtual look at Epstein–Barr virus infection: Simulation mechanism
- Source :
-
Journal of Theoretical Biology . Jun2008, Vol. 252 Issue 4, p633-648. 16p. - Publication Year :
- 2008
-
Abstract
- Abstract: Epstein–Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer''s ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death. [Copyright &y& Elsevier]
- Subjects :
- *EPSTEIN-Barr virus
*COMPUTER simulation
*T cells
*BLOOD
*LYMPH
*INFECTION
Subjects
Details
- Language :
- English
- ISSN :
- 00225193
- Volume :
- 252
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Theoretical Biology
- Publication Type :
- Academic Journal
- Accession number :
- 32501553
- Full Text :
- https://doi.org/10.1016/j.jtbi.2008.01.032