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4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jun2008, Vol. 18 Issue 12, p3541-3544. 4p. - Publication Year :
- 2008
-
Abstract
- Abstract: The T box transcription antitermination system is a riboswitch found primarily in Gram-positive bacteria which monitors the aminoacylation of the cognate tRNA and regulates a variety of amino acid-related genes. Novel 4,5-disubstituted oxazolidinones were identified as high affinity RNA molecular effectors that modulate the transcription antitermination function of the T box riboswitch. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 18
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 32555243
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.05.015