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Preventive effect of acetyl-L-carnitine on the thermal hypoalgesia in streptozotocin-induced diabetic mice
- Source :
-
European Journal of Pharmacology . Jul2008, Vol. 588 Issue 2/3, p213-216. 4p. - Publication Year :
- 2008
-
Abstract
- Abstract: Hypoalgesia is one of the serious complications in diabetes. Since there are few therapeutic treatments for this diabetic hypoalgesia, the present study was designed to examine the effect of acetyl-L-carnitine (ALC) on the changes of nociceptive threshold in diabetic mice. For prophylactic study, ALC was administered once daily from 1 day after the streptozotocin treatment. Diabetic mice showed shorter tail-flick latency at 1–4 weeks after the streptozotocin treatment and longer tail-flick latency at 6–9 weeks after the streptozotocin treatment. The shortened tail-flick latency in early stage of diabetic mice was not affected by prophylactic treatment with ALC. On the other hand, ALC dose-dependently improved the hypoalgesia in diabetic mice. For therapeutic study, ALC was administered once daily from 7 weeks after the streptozotocin treatment, when tail-flick latency was already prolonged. The therapeutic treatment with ALC also ameliorated the prolonged tail-flick latency in diabetic mice. Both prophylactic and therapeutic treatment with ALC did not affect the tail-flick latency in non-diabetic mice, indicating ALC did not affect the general nociceptive transmission. These results provide evidence of the prophylactic and therapeutic potential of ALC on the progressive diabetic neuropathy. [Copyright &y& Elsevier]
- Subjects :
- *CARNITINE
*VITAMIN B complex
*ANTINEOPLASTIC antibiotics
*IMMUNOSUPPRESSIVE agents
Subjects
Details
- Language :
- English
- ISSN :
- 00142999
- Volume :
- 588
- Issue :
- 2/3
- Database :
- Academic Search Index
- Journal :
- European Journal of Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 32645025
- Full Text :
- https://doi.org/10.1016/j.ejphar.2008.04.029