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Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation
- Source :
-
FEBS Letters . Jun2008, Vol. 582 Issue 15, p2325-2332. 8p. - Publication Year :
- 2008
-
Abstract
- Abstract: Recent studies show that human Pnas4 might be tumor associated, while its function remains unknown. Here, we investigate the developmental function of Pnas4 using zebrafish as a model system. Knocking down Pnas4 causes gastrulation defects with a shorter and broader axis, as well as a posteriorly mis-positioned prechordal plate, due to the defective convergence and extension movement. Conversely, over-expression of Pnas4 mRNA leads to an elongated body axis. We further demonstrate that Pnas4 is required cell-autonomously for dorsal convergence but not for anterior migration. In addition, genetic interaction assays indicate that Pnas4 might act in parallel with non-canonical Wnt signal in the regulation of cell movement. Our data suggest that Pnas4 is a key regulator of cell movement during gastrulation. [Copyright &y& Elsevier]
- Subjects :
- *GASTRULATION
*EMBRYOLOGY
*CELL motility
*CELL physiology
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 582
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 32645077
- Full Text :
- https://doi.org/10.1016/j.febslet.2008.05.036