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Mumps vaccination coverage and vaccine effectiveness in a large outbreak among college students—Iowa, 2006
- Source :
-
Vaccine . Jul2008, Vol. 26 Issue 29/30, p3601-3607. 7p. - Publication Year :
- 2008
-
Abstract
- Abstract: Following implementation of a routine childhood two-dose measles–mumps–rubella vaccination strategy, mumps disease levels dropped dramatically in the US and an elimination goal was set for 2010. However, a 2006 epidemic involved >5700 cases nationwide, with many reported among fully vaccinated college students. In an outbreak in two Iowa colleges, we investigated: (1) vaccination coverage using electronic records verified by provider records and (2) vaccine effectiveness assessed by comparison of dose-specific attack rates. Mumps was classified as typical (parotitis/orchitis) or atypical (parotid tenderness or submandibular/sublingual adenitis). Two-dose mumps vaccination coverage was 90% both for the student population (2128/2363) and case-students (97/108). Two-dose vaccine effectiveness was 76–88% with no significant difference for attack rates between one and two doses. Among two-dose vaccine recipients, 74% of the population (1482/2009) and 79% of the case-students (75/95) had received the second dose >10 years before. A large mumps outbreak occurred despite high two-dose vaccination coverage in a population most of whom had received the second dose >10 years before. Two-dose vaccine effectiveness was similar to previous one-dose estimates. Further studies are needed to examine the persistence of two-dose mumps vaccine-induced immunity and to determine whether US mumps elimination can be achieved with the current vaccination strategy. [Copyright &y& Elsevier]
- Subjects :
- *VIRUS diseases
*RUBELLA
*COLLEGE students
*IMMUNIZATION
Subjects
Details
- Language :
- English
- ISSN :
- 0264410X
- Volume :
- 26
- Issue :
- 29/30
- Database :
- Academic Search Index
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 32736289
- Full Text :
- https://doi.org/10.1016/j.vaccine.2008.04.075