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Common sequence variants on 20q11.22 confer melanoma susceptibility.
- Source :
-
Nature Genetics . Jul2008, Vol. 40 Issue 7, p838-840. 3p. 2 Graphs. - Publication Year :
- 2008
-
Abstract
- We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 × 10−15). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GENOMES
*MELANOMA
*CHROMOSOMES
*DISEASE risk factors
*GENETICS
Subjects
Details
- Language :
- English
- ISSN :
- 10614036
- Volume :
- 40
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Nature Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 32776709
- Full Text :
- https://doi.org/10.1038/ng.163