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The effects of sodium butyrate, an inhibitor of histone deacetylase, on the cocaine- and sucrose-maintained self-administration in rats
- Source :
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Neuroscience Letters . Aug2008, p72-76. 5p. - Publication Year :
- 2008
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Abstract
- Abstract: In order to substantiate the concept that cocaine behavioral effects may be influenced by histone modification, rats were trained to self-administer cocaine intravenously (0.75mg/(kginjection)), and were systemically pretreated with sodium butyrate (NaBu), a potent histone deacetylase inhibitor, before the test session during the maintenance phase. The effect of NaBu on a control reinforcer (sucrose)-induced self-administration was also assessed. NaBu (100–200mg/kg) was inactive in altering the cocaine (0.75mg/(kginjection))-maintained responding and at the highest dose (400mg/kg) it did increase cocaine-induced lever presses during the maintenance phase. On the other hand, sucrose-reinforcing potential was not altered when NaBu was given at the highest dose (400mg/kg). These findings extend previous observations that changes in histone acetylation are relevant to cocaine-induced behavioral effects. Given that histone acetylase inhibitor enhances cocaine-induced behavioral plasticity, the therapeutic benefits of histone acetyltransferase inhibitors warrant further investigation in the experimental models of cocaine abuse. [Copyright &y& Elsevier]
- Subjects :
- *HISTONES
*SUCROSE
*COCAINE
*NARCOTICS
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 32983379
- Full Text :
- https://doi.org/10.1016/j.neulet.2008.05.010