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Petalonia improves glucose homeostasis in streptozotocin-induced diabetic mice
- Source :
-
Biochemical & Biophysical Research Communications . Aug2008, Vol. 373 Issue 2, p265-269. 5p. - Publication Year :
- 2008
-
Abstract
- Abstract: The anti-diabetic potential of Petalonia binghamiae extract (PBE) was evaluated in vivo. Dietary administration of PBE to streptozotocin (STZ)-induced diabetic mice significantly lowered blood glucose levels and improved glucose tolerance. The mode of action by which PBE attenuated diabetes was investigated in vitro using 3T3-L1 cells. PBE treatment stimulated 3T3-L1 adipocyte differentiation as evidenced by increased triglyceride accumulation. At the molecular level, peroxisome proliferator-activated receptor γ (PPARγ) and terminal marker protein aP2, as well as the mRNA of GLUT4 were up-regulated by PBE. In mature adipocytes, PBE significantly stimulated the uptake of glucose and the expression of insulin receptor substrate-1 (IRS-1). Furthermore, PBE increased PPARγ luciferase reporter gene activity in COS-1 cells. Taken together, these results suggest that the in vivo anti-diabetic effect of PBE is mediated by both insulin-like and insulin-sensitizing actions in adipocytes. [Copyright &y& Elsevier]
- Subjects :
- *HOMEOSTASIS
*PEOPLE with diabetes
*GLUCOSE
*IMMUNOSUPPRESSIVE agents
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 373
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 32987677
- Full Text :
- https://doi.org/10.1016/j.bbrc.2008.06.015