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A Facile and Modular Synthesis of Phosphinooxazoline Ligands.

Authors :
Kousuke Tani
Douglas C. Behenna
Ryan M. McFadden
Brian M. Stoltz
Source :
Organic Letters. Jun2007, Vol. 9 Issue 13, p2529-2531. 3p.
Publication Year :
2007

Abstract

The copper(I) iodide catalyzed phosphine/aryl halide coupling procedure of Buchwald et al. provides modular, robust, and scaleable access to phosphinooxazoline (PHOX) ligands. The advantages of this method are highlighted by the convenient synthesis of PHOX ligands with varied steric and electronic properties, which would be challenging to synthesize by other protocols. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15237060
Volume :
9
Issue :
13
Database :
Academic Search Index
Journal :
Organic Letters
Publication Type :
Academic Journal
Accession number :
33261037
Full Text :
https://doi.org/10.1021/ol070884s