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14-3-3 regulates the G2/M transition in the basidiomycete Ustilago maydis
- Source :
-
Fungal Genetics & Biology . Aug2008, Vol. 45 Issue 8, p1206-1215. 10p. - Publication Year :
- 2008
-
Abstract
- Abstract: 14-3-3 proteins are a family of highly conserved polypeptides that function as small adaptors that facilitate a diverse array of cellular processes by binding phosphorylated target proteins. One of these processes is the regulation of the cell cycle. Here we characterized the role of Bmh1, a 14-3-3 protein, in the cell cycle regulation of the fungus Ustilago maydis. We found that this protein is essential in U. maydis and that it has roles during the G2/M transition in this organism. The function of 14-3-3 in U. maydis seems to mirror the proposed role for this protein during Schizosaccharomyces pombe cell cycle regulation. We provided evidence that in U. maydis 14-3-3 protein binds to the mitotic regulator Cdc25. Comparison of the roles of 14-3-3 during cell cycle regulation in other fungal system let us to discuss the connections between morphogenesis, cell cycle regulation and the evolutionary role of 14-3-3 proteins in fungi. [Copyright &y& Elsevier]
- Subjects :
- *BASIDIOMYCETES
*USTILAGO maydis
*POLYPEPTIDES
*FUNGI
Subjects
Details
- Language :
- English
- ISSN :
- 10871845
- Volume :
- 45
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Fungal Genetics & Biology
- Publication Type :
- Academic Journal
- Accession number :
- 33347118
- Full Text :
- https://doi.org/10.1016/j.fgb.2008.05.010