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A prospective randomized trial of acute tocolysis in term labour with atosiban or ritodrine
- Source :
-
European Journal of Obstetrics & Gynecology & Reproductive Biology . Aug2008, Vol. 139 Issue 2, p139-145. 7p. - Publication Year :
- 2008
-
Abstract
- Abstract: Objective: To study the effects of the tocolytics atosiban and ritodrine in term labour. Study design: Women in term labour, requiring acute tocolysis, were prospectively randomized for treatment with either atosiban i.v. (n =70) or ritodrine i.v. (n =70). There were three indications for acute tocolysis: (1) fetal distress followed by continuation of labour, (2) fetal distress followed by emergency caesarean section (CS), and (3) arrest of contractions in women waiting for a secondary CS in the absence of fetal distress. Primary endpoints were maternal blood pressure (MBP) and maternal heart rate (MHR). Secondary endpoints were intra-uterine pressure, fetal heart rate (FHR), 5′-Apgar score and umbilical arterial pH. Results: Baseline characteristics did not differ between the study groups. The ritodrine group showed a significant rise in MHR (p <0.001), MHR remained unaltered in the atosiban group (p =0.31). No significant changes occurred in systolic and diastolic BP in either group. FHR rose by a maximum of 11.6bpm (8.5%) in the ritodrine group (p <0.001) compared to a rise of 4.9bpm (4.8%) in the atosiban group (p =0.27). No differences were found in blood loss and fetal outcome. Compared to baseline, uterine pressure was reduced by a maximum of 55% (p <0.001) after ritodrine administration, compared to a maximal reduction of 54% (p <0.001) after atosiban administration. These effects did not differ between the two treatment groups. Conclusion: Considering the maternal effects, our results suggest a possible role for atosiban bolus in acute tocolysis in term labour. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03012115
- Volume :
- 139
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- European Journal of Obstetrics & Gynecology & Reproductive Biology
- Publication Type :
- Academic Journal
- Accession number :
- 33530074
- Full Text :
- https://doi.org/10.1016/j.ejogrb.2008.01.001