Making the paper: David Colquhoun & Lucia Sivilotti.

The article reports on the discovery of David Colquhoun and Lucia Sivilotti on the mechanism that explains the response of receptors to partial agonists in London, England. It reveals that many drugs work by binding to a specific cell receptors and stimulating its activity triggers a cascade of events in the cell. These drugs and the naturally occurring chemicals with the same modus operandi are called agonists but some of these elicit a powerful response while others generate smaller responses even at high levels to occupy all the available receptors. Both of them discovered a new mechanism to explain how receptors respond to partial agonists wherein they found that agonist-bound receptor can exist in one of three states, resting, partially activated or flipped from resting.