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Characterization of Sequence-Specific DNA Binding by the Transcription Factor Oct-1.
- Source :
-
Biochemistry . 06/27/2000, Vol. 39 Issue 25, p7570. 10p. 4 Black and White Photographs, 2 Diagrams, 2 Charts, 7 Graphs. - Publication Year :
- 2000
-
Abstract
- Characterizes the binding of the Oct-1 transcription factor (Oct-1/POU) to an octamer element using isothermal titration calorimetry. Large negative capacity change during the formation of the Oct-1/POU/DNA complex; Dependence of the formation of the complex on ionic strength; Charge contacts between the protein and the phosphate groups of the DNA.
- Subjects :
- *TRANSCRIPTION factors
*PROTEIN binding
*CALORIMETRY
*DNA
*COMPLEX compounds
Subjects
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 39
- Issue :
- 25
- Database :
- Academic Search Index
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 3353778
- Full Text :
- https://doi.org/10.1021/bi000377h