Interaction of Salmonella enterica serovar Typhi with cultured epithelial cells: roles of surface structures in adhesion and invasion.

The article presents the study conducted regarding the ability of Salmonella enterica serovar Typhi (S. Typhi) surface structure to regulate invasion and adhesion in the epithelial cell assay systems. S. Typhi is less adherent, cytotxic and invasive compared to S. enterica serovar Typhimurium in culture conditions. Its level of invasion also increases through the application of bacteria on the basolateral surface of polarized cells. Its expression of virulence (Vi) capsule resulted to modest reduction in adhesion and reduce the invasion level of non-polarized cells. Results of the study are discussed in the article.