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A novel peptide from α5 helix of Asterina pectinifera cyclin B conjugated to HIV-Tat49–57 with cytotoxic and apoptotic effects against human cancer cells
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Aug2008, Vol. 18 Issue 16, p4633-4637. 5p. - Publication Year :
- 2008
-
Abstract
- Abstract: A series of novel peptides from various motifs of Asterina pectinifera cyclin B and their derivatives conjugated to HIV-Tat49–57 were designed and synthesized. Their bioactivities on two human cancer cell lines were determined. Among them, Tat-a5 (KAQIRAMECNILGRKKRRQRRR) exhibited significant cytotoxic effects on cancer cell lines EC-9706 and HCT-116. Tat-a5 could arrest cancer cells at G2/M phase and make them apoptotic. Our results suggested that Tat-a5 could be a novel leading peptide with anticancer activity. [Copyright &y& Elsevier]
- Subjects :
- *CANCER cells
*CELL culture
*APOPTOSIS
*CELL lines
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 18
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 33630147
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.07.017