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Anti-HBV agents. Part 1: Synthesis of alisol A derivatives: A new class of hepatitis B virus inhibitors
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Aug2008, Vol. 18 Issue 16, p4647-4650. 4p. - Publication Year :
- 2008
-
Abstract
- Abstract: A series of alisol A derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activities and cytotoxicities in vitro. The preliminary investigation demonstrates that simple modifications of the parent structure of alisol A can produce a number of potentially important derivatives against HBV. The most active anti-HBV compound 6a showed high activities against the secretion of HBV surface antigen (IC50 =0.024mM), HBV e antigen (IC50 =0.028mM) and remarkable selective indices (SIHBsAg >108, SIHBeAg >93), which was selected for further evaluation as a novel HBV inhibitor. [Copyright &y& Elsevier]
- Subjects :
- *HEPATITIS B virus
*HEPATITIS viruses
*LIVER diseases
*VIRAL hepatitis
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 18
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 33630150
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.07.012