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Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88)
- Source :
-
Developmental & Comparative Immunology . Dec2008, Vol. 32 Issue 12, p1522-1530. 9p. - Publication Year :
- 2008
-
Abstract
- Summary: Myeloid differentiation factor 88 (MyD88) is an adaptor protein involved in the interleukin-1 receptor- and Toll-like receptor-induced activation of nuclear factor-κB (NF-κB). A novel isoform of chicken MyD88, designated chicken MyD88-2, has been cloned and functionally characterized. Its open reading frame is of length 900bp, and it encodes a predicted 299 residue protein, similar in length to its mammalian orthologues, but, respectively, 77 and 69 amino acids shorter than the previously described chicken MyD88-1 and -3. The amino acid sequence of chicken MyD88-2 displays 96.9%, 96.9%, 70.4% and 70.2% identity with, respectively, chicken MyD88-1, -3, human and mouse MyD88. Chicken MyD88-2 expression was detected in a range of tissues tested, but no expression of either chicken MyD88-1 or -3 was observed. The over-expression of chicken MyD88-2 significantly induced the activation of NF-κB in vitro, suggesting that chicken MyD88-2 plays an important role in the innate immune responses of chicken. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0145305X
- Volume :
- 32
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Developmental & Comparative Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 34053788
- Full Text :
- https://doi.org/10.1016/j.dci.2008.05.016