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Pathological and Prognostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin in Macroproteinuric Patients with Worsening Renal Function.
- Source :
-
Kidney & Blood Pressure Research . 2008, Vol. 31 Issue 4, p274-279. 6p. 2 Charts, 3 Graphs. - Publication Year :
- 2008
-
Abstract
- Background/Aims: Persistent proteinuria is a sign of renal damage caused by several factors, but it is itself a cause of tubular injury leading to chronic renal failure. Neutrophil gelatinase-associated lipocalin (NGAL) is a stress protein released by tubular cells which urinary excretion (uNGAL) increases in response to various stimuli. Methods: In the present study we analyzed uNGAL levels in 23 macroproteinuric patients with membranous glomerulonephritis. Results: In these subjects, uNGAL concentrations were significantly higher than in controls, directly correlated with proteinuria and inversely related to residual renal function. Patients were further categorized into two groups, according to a cut-off baseline uNGAL value of 350 ng/ml and evaluated during a 1-year follow-up period. After 12 months, subjects with higher uNGAL levels showed a significant worsening in baseline renal function and a 3.36 risk ratio of developing a severe decrease in GFR (≥50% of baseline values) compared with others. Conclusions: These findings suggest that NGAL may play a key role in tubular adaptations to persistent macroproteinuria. Furthermore, a new, interesting application of NGAL measurement could be proposed in clinical nephrology as a predictor of worsening renal function in patients affected by chronic kidney disease. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- *NEUTROPHILS
*KIDNEYS
*PROTEINURIA
*PROGNOSIS
*GLOMERULONEPHRITIS
Subjects
Details
- Language :
- English
- ISSN :
- 14204096
- Volume :
- 31
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Kidney & Blood Pressure Research
- Publication Type :
- Academic Journal
- Accession number :
- 34217340
- Full Text :
- https://doi.org/10.1159/000151665