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Local effects of TL01 phototherapy in psoriasis.
- Source :
-
Photodermatology, Photoimmunology & Photomedicine . Oct2008, Vol. 24 Issue 5, p268-269. 2p. 2 Graphs. - Publication Year :
- 2008
-
Abstract
- The mechanisms whereby narrowband ultraviolet B (UVB) (311–313 nm, TL01) phototherapy are effective in psoriasis may differ from those occurring in broadband UVB phototherapy. In the present study, changes in epidermal cells as a result of TL01 therapy were assessed in the skin of patients with psoriasis. The non-lesional skin of five subjects with plaque psoriasis was biopsied before and after a series of 12 whole-body TL01 treatments. Following appropriate staining of skin sections, the numbers of p53-positive keratinocytes, sunburn cells and Langerhans cells in the epidermis were counted. TL01 therapy induced a threefold increase in the number of p53-positive epidermal cells, a 12-fold increase in sunburn cells and a twofold decrease in Langerhans cells. The increase in epidermal p53 expression and apoptosis of keratinocytes together with the depletion of Langerhans cells in the non-lesional skin of psoriasis patients are likely to contribute to the effectiveness of TL01 phototherapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09054383
- Volume :
- 24
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Photodermatology, Photoimmunology & Photomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 34246454
- Full Text :
- https://doi.org/10.1111/j.1600-0781.2008.00366.x