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The Transcription Factor PLZF Directs the Effector Program of the NKT Cell Lineage
- Source :
-
Immunity (10747613) . Sep2008, Vol. 29 Issue 3, p391-403. 13p. - Publication Year :
- 2008
-
Abstract
- Summary: The transcriptional control of CD1d-restricted NKT cell development has remained elusive. We report that PLZF (promyelocytic leukemia zinc finger, Zbtb16), a member of the BTB/POZ-ZF family of transcription factors that includes the CD4-lineage-specific c-Krox (Th-POK), is exquisitely specific to CD1d-restricted NKT cells and human MR1-specific MAIT cells. PLZF was induced immediately after positive selection of NKT cell precursors, and PLZF-deficient NKT cells failed to undergo the intrathymic expansion and effector differentiation that characterize their lineage. Instead, they preserved a naive phenotype and were directed to lymph nodes. Conversely, transgenic expression of PLZF induced CD4+ thymocytes to acquire effector differentiation and migrate to nonlymphoid tissues. We suggest that PLZF is a transcriptional signature of NKT cells that directs their innate-like effector differentiation during thymic development. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 10747613
- Volume :
- 29
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Immunity (10747613)
- Publication Type :
- Academic Journal
- Accession number :
- 34299141
- Full Text :
- https://doi.org/10.1016/j.immuni.2008.07.011