Soluble Polymer-Supported Synthesis of 5-Arylidene Thiazolidinones and Pyrimidinones Using a Novel Traceless Linker Strategy.

An efficient method for the soluble polymer-supported synthesis of 5-arylidene thiazolidinones and pyrimidinones using aniline as a traceless linker was described. Aldehyde substrates were attached to the polyethylene glycol (PEG)-bound aniline via an imine linkage, and after the subsequent PEG-promoted Suzuki coupling reaction for the diversification, Knoevenagel condensation was readily employed as the cleavage strategy. [ABSTRACT FROM AUTHOR]