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Mouse γδ T cells are capable of expressing MHC class II molecules, and of functioning as antigen-presenting cells
- Source :
-
Journal of Neuroimmunology . Oct2008, Vol. 203 Issue 1, p3-11. 9p. - Publication Year :
- 2008
-
Abstract
- Abstract: Although human and bovine γδ T cells were shown to express MHC class II antigen and function as APCs, attempts to determine if mouse γδ T cells have similar functions remained unsuccessful. We now show that γδ T cells derived from immunized mice also can be induced to express MHC class II and co-stimulatory molecules after activation in vitro, and are capable of antigen presentation. Using highly purified γδ T cells, we found that, unlike human γδ T cells, the expression of MHC class II molecules by mouse γδ T cells is limited to newly activated cells. Highest levels of MHC class II expression were seen on activated γδ T cells that had lost most surface-expressed γδ TCR while exhibiting increased levels of intracellular γδ TCR. In the absence of further stimulation, MHC class II expression gradually declined with the γδ T cells regaining their surface TCR. We also show that cytokine-activated γδ T cells can also express MHC class II antigen and exercise antigen-presenting activity. [Copyright &y& Elsevier]
- Subjects :
- *MAJOR histocompatibility complex
*T cells
*ANTIGENS
*INTERLEUKINS
Subjects
Details
- Language :
- English
- ISSN :
- 01655728
- Volume :
- 203
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 34532083
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2008.06.007