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Pulsatile Stretch Induces Release of Angiotensin II and Oxidative Stress in Human Endothelial Cells: Effects of ACE Inhibition and AT1 Receptor Antagonism.
- Source :
-
Clinical & Experimental Hypertension . Oct2008, Vol. 30 Issue 7, p616-627. 12p. 1 Diagram, 5 Graphs. - Publication Year :
- 2008
-
Abstract
- Mechanical forces and the activation of the renin-angiotensin system (RAS) may alter the NO/O2•- balance, imparing endothelial nitric oxide (NO) availability. This study investigates the link between RAS and NO/O2•- balance in human aortic endothelial cells (HAEC) exposed to pulsatile stretch with and without ACE inhibitor quinaprilat or angiotensin II type 1 (AT1) receptor antagonist losartan. Pulsatile stretch increased Ang II levels and O2•- production, reducing NO release. RAS blockade with quinaprilat or losartan restored the balance between NO and O2•-. These results provide a molecular basis for understanding the vascular protective effects of ACE inhibition and AT1 receptor antagonism. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10641963
- Volume :
- 30
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 34741341
- Full Text :
- https://doi.org/10.1080/10641960802443183