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Selenium nanoparticles fabricated in Undaria pinnatifida polysaccharide solutions induce mitochondria-mediated apoptosis in A375 human melanoma cells
- Source :
-
Colloids & Surfaces B: Biointerfaces . Nov2008, Vol. 67 Issue 1, p26-31. 6p. - Publication Year :
- 2008
-
Abstract
- Abstract: Selenium nanoparticle (Nano-Se) is a novel Se species with novel biological activities and low toxicity. In the present study, we demonstrated a simple method for synthesis of size-controlled Nano-Se by adding Undaria pinnatifida polysaccharides to the redox system of selenite and ascorbic acid. A panel of four human cancer cell lines was shown to be susceptible to Nano-Se, with IC50 values ranging from 3.0 to 14.1μM. Treatment of A375 human melanoma cells with the Nano-Se resulted in dose-dependent cell apoptosis as indicated by DNA fragmentation and phosphatidylserine translocation. Further investigation on intracellular mechanisms found that Nano-Se treatment triggered apoptotic cell death in A375 cells with the involvement of oxidative stress and mitochondrial dysfunction. Our results suggest that Nano-Se may be a candidate for further evaluation as a chemopreventive and chemotherapeutic agent for human cancers, especially melanoma cancer. [Copyright &y& Elsevier]
- Subjects :
- *CELL death
*APOPTOSIS
*CANCER
*NEUROENDOCRINE tumors
Subjects
Details
- Language :
- English
- ISSN :
- 09277765
- Volume :
- 67
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Colloids & Surfaces B: Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 34743771
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2008.07.010