Clinical manifestations and natural history of Japanese heterozygous females with Fabry disease.

The article reports on the clinical features and natural history of Japanese heterozygous females with Anderson-Fabry disease (AFD). It states that acroparaesthesia and corneal opacities were the most common clinical manifestations, followed by proteinuria and left ventricular hypertrophy. It adds that as the clinical manifestations were found to develop increasingly with age, they underscore the need for monitoring as well as the introduction of enzyme therapy.