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Nicotinic Acid, Nicotinamide, and Nicotinainide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition.
- Source :
-
Annual Review of Nutrition . 2008, Vol. 28 Issue 1, p115-130. 17p. - Publication Year :
- 2008
-
Abstract
- Although baseline requirements for nicotinamide adenine dinucleotide (NAD+) synthesis can be met either with dietary tryptophan or with less than 20 mg of daily niacin, which consists of nicotinic acid and/or nicotinamide, there is growing evidence that substantially greater rates of NAD+ synthesis may be beneficial to protect against neurological degeneration, Candida glabrata infection, and possibly to enhance reverse cholesterol transport. The distinct and tissue-Specific biosynthetic and/or ligand activities of tryptophan, nicotinic acid, nicotinamide, and the newly identified NAD+ precursor, nicotinamide riboside, reviewed herein, are responsible for vitamin-specific effects and side effects. Because current data suggest that nicotinamide riboside may be the only vitamin precursor that supports nenronal NAD+ synthesis, we present prospects for human nicotinamide riboside supplementation and propose areas for future research. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NICOTINAMIDE
*NIACIN
*AMIDES
*NUTRITION
*VITAMINS
*NEURODEGENERATION
*BIOSYNTHESIS
Subjects
Details
- Language :
- English
- ISSN :
- 01999885
- Volume :
- 28
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Annual Review of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 34874625
- Full Text :
- https://doi.org/10.1146/annurev.nutr.28.061807.155443