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High-Dose Riboflavin for Migraine Prophylaxis in Children: A Double-Blind, Randomized, Placebo-Controlled Trial.
- Source :
-
Journal of Child Neurology . Nov2008, Vol. 23 Issue 11, p1300-1304. 5p. 1 Diagram, 1 Chart, 2 Graphs. - Publication Year :
- 2008
-
Abstract
- This is the first study to evaluate the efficacy of riboflavin for migraine prophylaxis in children. This was a randomized, double-blind study of riboflavin (200 mg daily) versus placebo in 48 children. The primary efficacy measure was the number of patients achieving a 50% or greater reduction in the number of migraine attacks per 4 weeks. Other outcome measures were the mean severity of migraine per day, mean duration of migraine, days with nausea or vomiting, analgesic use, and adverse effects. A 50% or greater reduction in headaches was seen in 14/21 patients in the placebo group and 12/27 patients in the riboflavin group (not significant P = .125). There were no differences between riboflavin and placebo for primary or secondary outcome variables. These results suggest that riboflavin is not an effective therapy for preventing migraine in children. A high placebo responder rate was seen, with implications for other studies of migraine in children. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VITAMIN B2
*MIGRAINE
*VOMITING
*ANALGESICS
*DRUG side effects
*PLACEBOS
Subjects
Details
- Language :
- English
- ISSN :
- 08830738
- Volume :
- 23
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Child Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 34948575
- Full Text :
- https://doi.org/10.1177/0883073808318053