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Neural Correlates of the Clock Drawing Test Performance in Alzheimer’s Disease: A FDG-PET Study.

Authors :
Dong Young Lee
Eun Hyun Seo
Il Han Choo
Shin Gyeom Kim
Jae Sung Lee
Dong Su Lee
Jin Hyeong Jhoo
Ki Woong Kim
Jong Choul Youn
Jong Inn Woo
Source :
Dementia & Geriatric Cognitive Disorders. 2008, Vol. 26 Issue 4, p306-313. 8p. 2 Color Photographs, 3 Charts, 1 Graph.
Publication Year :
2008

Abstract

Background/Aim: This study aimed to identify the functional neuroanatomical correlates of impaired clock drawing test (CDT) performance in patients with Alzheimer’s disease (AD). Method: The CDT was administered to 71 patients with AD, and regional cerebral glucose metabolism (rCMglc) was measured by positron emission tomography (PET). Correlations between CDT scores and rCMglc were examined on a voxel-by-voxel basis. Results: Significant positive correlations were found between CDT performance and rCMglc in the right inferior parietal lobule and right posterior cingulate cortex. Conclusion: These results provide the first PET evidence that poor CDT performance in patients with AD is closely related to the functional decline in the right hemisphere, especially the right parietal cortex. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14208008
Volume :
26
Issue :
4
Database :
Academic Search Index
Journal :
Dementia & Geriatric Cognitive Disorders
Publication Type :
Academic Journal
Accession number :
34998224
Full Text :
https://doi.org/10.1159/000161055