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Prevalence of genetically defined tumor cells in CD7 as well as CD26 positive and negative circulating T-cell subsets in Sézary syndrome
- Source :
-
Leukemia Research . Jan2009, Vol. 33 Issue 1, p88-99. 12p. - Publication Year :
- 2009
-
Abstract
- Abstract: For diagnosis and monitoring of Sézary syndrome flow cytometric quantification of CD7− and CD26− T-cells is widely used. Because antigen loss is a characteristic but not disease-specific finding we investigated the significance of this approach. Therefore we analyzed the prevalence of tumor cells in FACS-sorted CD7+/− as well as CD26+/− circulating T-cells applying a clone-specific qualitative and quantitative T-cell receptor PCR. Tumor cells varied considerably in the CD7+ and CD7− cell subset but were largely confined to the CD26− population. We conclude that quantification of CD26− T-cells reflects the tumor cell amount more accurate and should be preferred in the clinical setting. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01452126
- Volume :
- 33
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Leukemia Research
- Publication Type :
- Academic Journal
- Accession number :
- 35072552
- Full Text :
- https://doi.org/10.1016/j.leukres.2008.06.025