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Neural-Activity-Dependent Release of S100B from Astrocytes Enhances Kainate-Induced Gamma Oscillations In Vivo.
- Source :
-
Journal of Neuroscience . 10/22/2008, Vol. 28 Issue 43, p10928-10936. 9p. 1 Diagram, 7 Graphs. - Publication Year :
- 2008
-
Abstract
- S100B is the principal calcium-binding protein of astrocytes and known to be secreted to extracellular space. Although secreted S100B has been reported to promote neurite extension and cell survival via its receptor [receptor for advanced glycation end products (RAGE)], effects of extracellular S100B on neural activity have been mostly unexplored. Here, we demonstrate that secreted S100B enhances kainate-induced gamma oscillations. Local infusion of S100B in S100B(-/-) mice enhanced hippocampal kainate-induced gamma oscillations in vivo. In a complementary set of experiments, local application of anti-S100B antibody in wild-type mice attenuated the gamma oscillations. Both results indicate that the presence of extracellular S100B enhances the kainate-induced gamma oscillations. In acutely isolated hippocampal slices, kainate application increased S100B secretion in a neural-activity-dependent manner. Further pharmacological experiments revealed that S100B secretion was critically dependent on presynaptic release of neurotransmitter and activation of metabotropic glutamate receptor 3. Moreover, the kainate-induced gamma oscillations were attenuated by the genetic deletion or antibody blockade of RAGE in vivo. These results suggest RAGE activation by S100B enhances the gamma oscillations. Together, we propose a novel pathway of neuron- glia communications-astrocytic release of S100B modulates neural network activity through RAGE activation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ASTROCYTES
*PROTEINS
*GLUTAMIC acid
*IMMUNOGLOBULINS
*OSCILLATIONS
Subjects
Details
- Language :
- English
- ISSN :
- 02706474
- Volume :
- 28
- Issue :
- 43
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 35128033
- Full Text :
- https://doi.org/10.1523/JNEUROSCI.3693-08.2008