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Numerical study of IP3-induced Ca2+ spiral pattern evolution.
- Source :
-
Chinese Physics B . Nov2008, Vol. 17 Issue 11, p4100-4106. 7p. - Publication Year :
- 2008
-
Abstract
- The effect of change in concentration of messenger molecule inositol 1,4,5-trisphosphate (IP3) on intracellular Ca2+ spiral pattern evolution is studied numerically. The results indicate that when the IP3 concentration decreases from 0.27 mM, a physiologically reasonable value, to different values, the spiral centre drifts to the edge of the medium and disappears for a small enough IP3 concentration. The instability of spiral pattern can be understood in terms of excitability-change controlled by the IP3 concentration. On the other hand, when the IP3 concentration increases from 0.27 mM, a homogeneous area with a high Ca2+ concentration emerges and competes with the spiral pattern. A high enough IP3 concentration can lead the homogeneous area to occupy the whole medium. The instability of spiral pattern is ascribed to the change in stability of a stationary state with a high Ca2+ concentration. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16741056
- Volume :
- 17
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Chinese Physics B
- Publication Type :
- Academic Journal
- Accession number :
- 35490962
- Full Text :
- https://doi.org/10.1088/1674-1056/17/11/024