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Hypofractionated versus standard fractionation radiotherapy in early glottic cancer: A retrospective review.
- Source :
-
Asia Pacific Journal of Clinical Oncology . Dec2008, Vol. 4 Issue 4, p239-243. 5p. 3 Charts, 5 Graphs. - Publication Year :
- 2008
-
Abstract
- Aim: This retrospective review was conducted to compare outcomes using different fractionation schedules for early stage glottic cancer treated with radiotherapy between 1991 and 2003. Methods: The records of 87 patients with either T1 or T2 squamous cell carcinomas of the glottic larynx were analysed, dividing the patients into those treated with a hypofractionated schedule, mostly 51 Gy/16# (<53 Gy) and standard fractionation, minimum 60 Gy/30# in 2 Gy fractions. The median follow up was 4 years and 7 months. Results: Local control at 5 years was 81% with standard fractionation vs 93% in the hypofractionated group ( P = 0.1). Laryngectomy free survival at 5 years was 78% with standard fractionation versus 95% in the hypofractionated arm ( P = 0.017). Overall survival at 5 years was 65%with standard fractionation versus 74% in the hypofractionated arm ( P = 0.55). Conclusion: In early stage glottic cancer, a hypofractionated course of radiotherapy has been shown to be a safe and possibly more effective treatment compared with standard fractionation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RADIOTHERAPY
*GLOTTIS cancer
*CANCER
*MEDICAL electronics
*MEDICAL radiology
Subjects
Details
- Language :
- English
- ISSN :
- 17437555
- Volume :
- 4
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Asia Pacific Journal of Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 35641416
- Full Text :
- https://doi.org/10.1111/j.1743-7563.2008.00216.x