BIOTRANSFORMATION OF ACRIDINE BY MYCOBACTERIUM VANBAALENII.

Authors :: SUTHERLAND, JOHN B.
HEINZE, THOMAS M.
PEARCE, MASON G.
DECK, JOANNA
WILLIAMS, ANNA J.
FREEMAN, JAMES P.
Source :: Environmental Toxicology & Chemistry. Jan2009, Vol. 28 Issue 1, p61-64. 4p. 1 Diagram, 2 Charts, 1 Graph.
Publication Year :: 2009
Abstract: Cultures of Mycobacterium vanbaalenii strain PYR-1 in a liquid medium were exposed to the toxic environmental contaminant acridine (260 μM). After incubation for 7 d, the cultures were extracted with ethyl acetate. Metabolites were purified using high-performance liquid chromatography and analyzed by mass spectrometry and 1H nuclear magnetic resonance spectroscopy. Four metabolites, 9,10-dihydroacridine, 4-hydroxyacridine, acridine cis-1,2-dihydrodiol, and acridin-9(10H)-one, were identified. [ABSTRACT FROM AUTHOR]