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Au-Catalyzed Cyclization of Monopropargylic Triols: An Expedient Synthesis of Monounsaturated Spiroketals.
- Source :
-
Organic Letters . Jan2009, Vol. 11 Issue 1, p121-124. 4p. - Publication Year :
- 2009
-
Abstract
- The gold-catalyzed cyclization of monopropargylic triols to form olefin-containing spiroketals is reported. The reactions are rapid and high yielding when 2 mol % of the catalyst generated in situ from Au[P(t-Bu)2(o-biphenyl)]Cl and AgOTf is employed in THF at 0 °C. A range of differentially substituted triols leading to substituted 5- and 6-membered ring spiroketals were prepared and function well in the reaction. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 11
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 35873516
- Full Text :
- https://doi.org/10.1021/ol802491m