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Advances in the Treatment of Fragile X Syndrome.
- Source :
-
Pediatrics . Jan2009, Vol. 123 Issue 1, p378-390. 3p. 1 Color Photograph, 2 Diagrams. - Publication Year :
- 2009
-
Abstract
- The FMR1 mutations can cause a variety of disabilities, including cognitive deficits, attention-deficit/hyperactivity disorder, autism, and other socioemotional problems, in individuals with the full mutation form (fragile X syndrome) and distinct difficulties, including primary ovarian insufficiency, neuropathy and the fragile X-associated tremor/ataxia syndrome, in some older premutation carriers. Therefore, multigenerational family involvement is commonly encountered when a proband is identified with a FMRI mutation. Studies of metabotropic glutamate receptor 5 pathway antagonists in animal models of fragile X syndrome have demonstrated benefits in reducing seizures, improving behavior, and enhancing cognition. Trials of metabotropic glutamate receptor 5 antagonists are beginning with individuals with fragile X syndrome. Targeted treatments, medical and behavioral interventions, genetic counseling, and family supports are reviewed here. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00314005
- Volume :
- 123
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 36094247
- Full Text :
- https://doi.org/10.1542/peds.2008-0317