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Mean intraocular pressure and progression based on corneal thickness in patients with ocular hypertension.
- Source :
-
Eye . Jan2009, Vol. 23 Issue 1, p73-78. 6p. 5 Charts, 1 Graph. - Publication Year :
- 2009
-
Abstract
- PurposeTo determine the incidence of glaucomatous progression at mean intraocular pressure (IOP) levels in patients with ocular hypertension (OHT).MethodsA retrospective, multicentre, cohort analysis of 230 OHT patients with 5 years of follow-up evaluated for risk factors associated with progressive optic disc and visual field loss to determine the incidence of glaucomatous progression.ResultsForty percent of patients with IOPs 24 mmHg, 18% of patients with IOPs of 21–23 mmHg, 11% of patients with IOPs with 18–20 mmHg, and 3% of patients with IOPs of 17 mmHg progressed to glaucoma. The mean IOP was 19.8±2.4 mmHg in the stable group and 21.7±2.6 mmHg in the progressed group (P=0.0004). The highest average peak IOP was 23.4±4.0 mmHg in the stable group and 25.2±3.1 mmHg in the progressed group (P=0.006). Based on the pachymetry values for central corneal thickness, patients with thinner corneas more often progressed to glaucoma (P<0.0001). A multivariant regression analysis to determine risk factors for progression was positive primarily for higher peak IOPs, older age, male gender, argon laser trabeculoplasty, visual acuity 20/50, and no topical medical therapy or β-blocker therapy prior to the study.ConclusionsIOP reduction within the normal range over 5 years of follow-up reduces the chance of progression to primary open-angle glaucoma in OHT patients.Eye (2009) 23, 73–78; doi:10.1038/sj.eye.6702995; published online 5 October 2007 [ABSTRACT FROM AUTHOR]
- Subjects :
- *EYE diseases
*INTRAOCULAR pressure
*CORNEA
*HYPERTENSION
*GLAUCOMA
Subjects
Details
- Language :
- English
- ISSN :
- 0950222X
- Volume :
- 23
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Eye
- Publication Type :
- Academic Journal
- Accession number :
- 36113199
- Full Text :
- https://doi.org/10.1038/sj.eye.6702995